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<p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)">Update (4/10/25): <p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)"> Exciting news! The community raised enough money to cover all of the samples. We don’t have to raise the full $7k, because a lab has offered to run them for lower cost, so we're stopping the fundraising campaign early! 🙌  Andrew Gold saw the fundraiser posts in here thanks to everyone sharing & reached out to me to offer lower cost metabolomics testing.  Andrew is a PhD student in the Zhu lab at Ohio State. The Zhu lab develops technologies using mass spectrometry-based metabolomics, in combination with advanced chemometrics, for the sensitive, reliable and non-invasive detection and monitoring of human diseases. <span fr-original-style="font-size:11pt;font-family:Arial,sans-serif;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;" style="font-size:11pt;font-family:Arial, sans-serif;color:rgb(0, 0, 0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;box-sizing:inherit">_____________________________________<p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)"><a href="https://www.vassar.edu/faculty/daesteban" style="box-sizing:inherit;text-decoration-color:initial;user-select:auto">David Esteban</a>, a professor at Vassar, is running a study looking at specific microbial metabolites in Long COVID. He has done a similar study in ME/CFS, funded by <a href="https://solvecfs.org/research-and-registry/ramsay-research-grants/meet-the-researchers/david-esteban/" style="text-decoration-color:initial;user-select:auto;box-sizing:inherit">SolveME</a>, and gotten interesting results! (<a href="https://www.youtube.com/watch?v=WNm-MeVDA9I" style="text-decoration-color:initial;user-select:auto;box-sizing:inherit">Watch a recording of a talk about the ME/CFS results.</a>)<p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)"> <p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)">This project, studying the same metabolites in Long COVID, was funded by the <a href="https://patientresearchcovid19.com/" style="box-sizing:inherit;text-decoration-color:initial;user-select:auto">Patient-Led Research Collaborative</a>. We are raising additional funds for him to be able to analyze more samples that he has already collected.  <p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)"> <p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)">What your donations will go toward:<ul><li style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin-top:0px;margin-right:0px;margin-bottom:0px;line-height:1.5;color:rgb(0, 0, 0)">Each sample costs $295 to analyze. </li><li style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin-top:0px;margin-right:0px;margin-bottom:0px;line-height:1.5;color:rgb(0, 0, 0)">There is currently enough in the budget to analyze 20 samples.</li><li style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin-top:0px;margin-right:0px;margin-bottom:0px;line-height:1.5;color:rgb(0, 0, 0)">Dr. Esteban has 23 additional samples that are ready to go if he can raise this additional funding. (If he is able to analyze them, it will add significantly to the impact of this study!)</li></ul><p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)"> <p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)">____________________________________________________________________________________________<p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)">Description of the study from Vassar: <p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)"> <p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)">David Esteban Awarded Patient-Led Research Collaborative Award<p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)"> <p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)">David Esteban, Associate Professor of Biology, received one of nine research grants made by the Patient-Led Research Collaborative in support of his project entitled “Microbial metabolites as disease-modifying factors in Long-COVID.” The Patient-Led Research Collaborative supports research into Long COVID and associated conditions and also advocates for policies that enable patients.<p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)"> <p style="box-sizing:inherit;width:683.594px;font-family:Roboto, Helvetica, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;background-color:rgb(255, 255, 255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;margin:0px;line-height:1.5;color:rgb(0, 0, 0)">David’s research will investigate the production of, and response to, microbially derived AhR ligands in the microbiomes of people with Long COVID. Under healthy conditions, gut microbes produce an abundance of small molecules from tryptophan, which enter cells and activate the aryl hydrocarbon receptor (AhR). AhR induces expression of genes that limit inflammation and maintain the gut barrier. These ligands can also cross into the bloodstream and activate AhR distally to control inflammation and other processes. Under certain disease conditions, an altered microbial community is less able to produce AhR ligands from tryptophan. AhR therefore does not maintain the gut barrier and does not help control inflammation, while pro-inflammatory bacterial components are allowed to cross into the bloodstream. Due to the established connection between the gut microbiome, brain, and immune system, David’s foundational research will be critical in understanding the basis of neuroinflammation, immune dysfunction, and gastrointestinal homeostasis, in post-infectious chronic diseases. This study expands his ongoing research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) allowing comparison of these closely related diseases.

Hello <span contenteditable="false" data-custom-variable="{{firstname}}" fr-original-class="fr-deletable styled-tag-chip" fr-original-style style="background-color:rgb(248, 248, 255);border:1px solid rgb(191, 191, 255);border-radius:4px;color:rgb(42, 42, 196);padding:1px 8px;font-size:11px;display:inline-block;margin:0px;overflow-wrap:anywhere;user-select:none;box-sizing:inherit">First name, Thank you from the bottom of our hearts for supporting David Esteban's study! Cheers,The Renegade Research Team funding@renegade-research.org

Hello First name,
 
 Thank you from the bottom of our hearts for registering to fundraise for our cause. Your efforts will make a significant impact, and we are excited to have you as part of our fundraising team. 👏
 
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 Renegade Research funding@renegade-research.org

<p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%">Update (4/10/25): <p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%"> Exciting news! The community raised enough money to cover all of the samples. We don’t have to raise the full $7k, because a lab has offered to run them for lower cost, so we're stopping the fundraising campaign early! 🙌  Andrew Gold saw the fundraiser posts in here thanks to everyone sharing &amp; reached out to me to offer lower cost metabolomics testing.  Andrew is a PhD student in the Zhu lab at Ohio State. The Zhu lab develops technologies using mass spectrometry-based metabolomics, in combination with advanced chemometrics, for the sensitive, reliable and non-invasive detection and monitoring of human diseases. _____________________________________<p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%"><a href="https://www.vassar.edu/faculty/daesteban">David Esteban</a>, a professor at Vassar, is running a study looking at specific microbial metabolites in Long COVID. He has done a similar study in ME/CFS, funded by <a href="https://solvecfs.org/research-and-registry/ramsay-research-grants/meet-the-researchers/david-esteban/">SolveME</a>, and gotten interesting results! (<a href="https://www.youtube.com/watch?v=WNm-MeVDA9I">Watch a recording of a talk about the ME/CFS results.</a>)<p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%"> <p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%">This project, studying the same metabolites in Long COVID, was funded by the <a href="https://patientresearchcovid19.com/">Patient-Led Research Collaborative</a>. We are raising additional funds for him to be able to analyze more samples that he has already collected.  <p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%"> <p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%">What your donations will go toward:<ul><li>Each sample costs $295 to analyze. </li><li>There is currently enough in the budget to analyze 20 samples.</li><li>Dr. Esteban has 23 additional samples that are ready to go if he can raise this additional funding. (If he is able to analyze them, it will add significantly to the impact of this study!)</li></ul><p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%"> <p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%">____________________________________________________________________________________________<p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%">Description of the study from Vassar: <p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%"> <p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%">David Esteban Awarded Patient-Led Research Collaborative Award<p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%"> <p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%">David Esteban, Associate Professor of Biology, received one of nine research grants made by the Patient-Led Research Collaborative in support of his project entitled “Microbial metabolites as disease-modifying factors in Long-COVID.” The Patient-Led Research Collaborative supports research into Long COVID and associated conditions and also advocates for policies that enable patients.<p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%"> <p style="box-sizing:inherit;width:683.594px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:0.25px;orphans:2;text-align:start;text-indent:0px;text-transform:none;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;white-space:normal;text-decoration-thickness:initial;text-decoration-style:initial;margin:0px;line-height:1.5;max-width:100%">David’s research will investigate the production of, and response to, microbially derived AhR ligands in the microbiomes of people with Long COVID. Under healthy conditions, gut microbes produce an abundance of small molecules from tryptophan, which enter cells and activate the aryl hydrocarbon receptor (AhR). AhR induces expression of genes that limit inflammation and maintain the gut barrier. These ligands can also cross into the bloodstream and activate AhR distally to control inflammation and other processes. Under certain disease conditions, an altered microbial community is less able to produce AhR ligands from tryptophan. AhR therefore does not maintain the gut barrier and does not help control inflammation, while pro-inflammatory bacterial components are allowed to cross into the bloodstream. Due to the established connection between the gut microbiome, brain, and immune system, David’s foundational research will be critical in understanding the basis of neuroinflammation, immune dysfunction, and gastrointestinal homeostasis, in post-infectious chronic diseases. This study expands his ongoing research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) allowing comparison of these closely related diseases.

Renegade Research

Support David Esteban's study on Microbial Metabolites in Long COVID

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