Substantial grants to organizations committed to long-term community health initiatives; typically exceed $25,000 and require Board approval after a 3–6 month review.

Must be a public charity under Section 501(c)(3) or a governmental unit/agency | May use a fiscal sponsor if organization lacks 501(c)(3) designation | Must support Saint Luke's target neighborhoods or serve Cuyahoga County

Board Grants

Resident-led grants awarded by the Resident Advancement Committee for neighborhood projects (gardens, pocket parks, mentoring, etc.); neighbors and small nonprofits within Saint Luke’s footprint can receive up to $6,000.

Applicant must be a resident of Buckeye–Shaker, Mt. Pleasant, or Woodland Hills | If applicant is not a 501(c)(3), must collaborate with a fiscal sponsor (501(c)(3)) | Available March–September annually

Community Grants

Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R21 Clinical Trial Optional)

Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R01 Clinical Trial Optional)

Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01 Clinical Trial Not Allowed)

NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required)

General grantmaking to nonprofit organizations; cycles alternate between people-focused funding (poverty alleviation, youth education, improved health outcomes) and an animal-focused cycle (animal welfare/protection). Eligibility and application windows are listed on the foundation's application page.

Must be a 501(c)(3) tax-exempt organization | Must be described in IRS section 509(a)(2) (or in certain cases 509(a)(3)) | Fund recipient organizations based in the United States (foundation funds efforts in United States, Sri Lanka, and India) — see page for scope | Final report must be submitted no more than 60 days after the end of the grant period and is required before a new application is reviewed | The foundation does not fund scholarships or direct financial awards to individuals | The foundation does not fund sectarian activities for religious organizations | The foundation does not fund political causes, candidates, organizations, or campaigns | The foundation does not fund sponsorship of events, conferences, or meetings | The foundation does not fund disease-specific initiatives and/or medical research | The foundation will not fund organizations that discriminate based on age, race, nationality, ethnicity, religion, cultural beliefs, disability, or sex

Board Grants

About this program

Eligibility

Geographic eligibility

Contact & website

Indigo Bishop

[email protected]

216-431-8010

saintlukesfoundation.org

Past recipients

2024

Burten Bell Carr Development Inc (Bbc)

$350,000

Cuyahoga Land Bank Charities

$335,000

Village Of Healing (Voh)

$333,000

Amalgamated Charitable Foundation

$332,500

The Association Of African American Cultural Gardens

$300,000

Cleveland Neighborhood Progress Inc (Cnp)

$250,000

East End Neighborhood House Inc (Eenh)

$250,000

Nupoint Community Development Corporation (Formerly Umdc)

$250,000

Environmental Health Watch (Ehw)

$250,000

Closes Sep 7, 2026

~$25K (579 grants)

Ohio

Similar Grants

Community Grants

Up to $6.0K

Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R21 Clinical Trial Optional)

~$820K

Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R01 Clinical Trial Optional)

~$820K

Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01 Clinical Trial Not Allowed)

~$820K

NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required)

~$820K

Chandramohan Family Foundation Grants

~$20K